Vol. 4 No. 1 (2024): Issue 4
Articles

The Preventive and Interventional Mechanisms of Omega-3 Polyunsaturated Fatty Acids in Krill Oil for Metabolic Diseases

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  • Pei-Min Lu
Pei-Min Lu
Reckitt Manon, Shanghai, China

Published 2024-12-10

Keywords

  • Omega-3 PUFAs,
  • Krill Oil,
  • Metabolic Diseases,
  • Randomized Clinical Trial,
  • Lipid Profiles,
  • Inflammatory Markers
    • ...More
    Less

How to Cite

Lu, P.-M. (2024). The Preventive and Interventional Mechanisms of Omega-3 Polyunsaturated Fatty Acids in Krill Oil for Metabolic Diseases. Journal of Computational Biology and Medicine, 4(1). Retrieved from https://journal.mri-pub.com/index.php/JCBM/article/view/31

Abstract

This study explores the preventive and interventional effects of omega-3 polyunsaturated fatty acids (PUFAs) in krill oil on metabolic diseases. Given the rising prevalence of conditions such as type 2 diabetes, hypertension, and dyslipidemia, understanding effective interventions is crucial. However, identifying reliable therapeutic agents poses significant challenges. To address this, we conducted a 24-month randomized, double-blind, placebo-controlled clinical trial involving 300 participants aged 25-65 years with diagnosed metabolic diseases. Participants were randomized into three groups: a placebo control group, a low-dose krill oil group receiving 500 mg daily, and a high-dose krill oil group receiving 1000 mg daily. Data on blood glucose levels, blood pressure, lipid profiles, and inflammatory markers were collected at baseline and at 6, 12, 18, and 24 months. Our results revealed significant improvements in metabolic parameters among the krill oil groups compared to the control group. The low-dose group demonstrated moderate benefits, whereas the high-dose group showed more pronounced effects. Notable improvements were observed in blood glucose levels, blood pressure, lipid profiles (including LDL, HDL, and LDL/HDL ratio), and inflammatory markers (CRP levels). Statistical analyses, including ANOVA, regression models, and dose-response assessments, confirmed the efficacy of krill oil in modulating these parameters. This study provides robust evidence supporting the preventive and interventional roles of omega-3 PUFAs in krill oil, highlighting its potential as a novel therapeutic strategy for metabolic diseases.

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References

  1. (2020). Omega-3 Polyunsaturated Fatty Acids. Encyclopedia of Behavioral Medicine. https://doi.org/10.1007/978-3-030-39903-0_301324
  2. M. Hull (2011). Omega-3 polyunsaturated fatty acids.. Best practice & research. Clinical gastroenterology, 25 4-5, 547-54 . https://doi.org/10.1016/j.bpg.2011.08.001
  3. P. Calder (2013). Omega 3 polyunsaturated fatty acids
  4. F. Shahidi, P. Ambigaipalan (2018). Omega-3 Polyunsaturated Fatty Acids and Their Health Benefits.. Annual review of food science and technology, 9, 345-381 . https://doi.org/10.1146/annurev-food-111317-095850
  5. I. Djuricić, P. Calder (2021). Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021. Nutrients, 13. https://doi.org/10.3390/nu13072421
  6. I. Dighriri et al. (2022). Effects of Omega-3 Polyunsaturated Fatty Acids on Brain Functions: A Systematic Review. Cureus, 14. https://doi.org/10.7759/cureus.30091
  7. Yawei Fu et al. (2021). Associations among Dietary Omega-3 Polyunsaturated Fatty Acids, the Gut Microbiota, and Intestinal Immunity. Mediators of Inflammation, 2021. https://doi.org/10.1155/2021/8879227
  8. R. Saini et al. (2021). Omega−3 Polyunsaturated Fatty Acids (PUFAs): Emerging Plant and Microbial Sources, Oxidative Stability, Bioavailability, and Health Benefits—A Review. Antioxidants, 10. https://doi.org/10.3390/antiox10101627
  9. A. Elagizi et al. (2021). An Update on Omega-3 Polyunsaturated Fatty Acids and Cardiovascular Health. Nutrients, 13. https://doi.org/10.3390/nu13010204
  10. D. Fu et al. (2023). Development and characterization of self-emulsifying high internal phase emulsions using endogenous phospholipids from Antarctic krill oil.. Food chemistry, 428, 136765 . https://doi.org/10.1016/j.foodchem.2023.136765
  11. Tyler Barker et al. (2023). A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of a Krill Oil, Astaxanthin, and Oral Hyaluronic Acid Complex on Joint Health in People with Mild Osteoarthritis. Nutrients, 15. https://doi.org/10.3390/nu15173769
  12. Chang Xu et al. (2023). Evaluation of the Role of Soybean Lecithin, Egg Yolk Lecithin, and Krill Oil in Promoting Ovarian Development in the Female Redclaw Crayfish Cherax quadricarinatus. Aquaculture Nutrition, 2023. https://doi.org/10.1155/2023/6925320
  13. Franziska Vosskötter et al. (2023). Equal bioavailability of omega-3 PUFA from Calanus oil, fish oil and krill oil: A 12-week randomized parallel study.. Lipids. https://doi.org/10.1002/lipd.12369
  14. Fangchao Cui et al. (2023). Effect of Maillard conjugates of peptides and polydextrose on Antarctic krill oil emulsion stability and digestibility. LWT. https://doi.org/10.1016/j.lwt.2023.114648
  15. Jongkyu Kim et al. (2023). Krill Oil’s Protective Benefits against Ultraviolet B-Induced Skin Photoaging in Hairless Mice and In Vitro Experiments. Marine Drugs, 21. https://doi.org/10.3390/md21090479
  16. H. Zhang et al. (2023). Krill oil treatment ameliorates lipid metabolism imbalance in chronic unpredicted mild stress-induced depression-like behavior in mice. Frontiers in Cell and Developmental Biology, 11. https://doi.org/10.3389/fcell.2023.1180483
  17. Cheng-Cheng Wang et al. (2023). Antarctic krill oil exhibited synergistic effects with nobiletin and theanine on regulating ligand-specific receptor-mediated transcytosis in blood-brain barrier by inhibiting alkaline phosphatase in SAMP8 mice.. Molecular nutrition & food research, e2200825 . https://doi.org/10.1002/mnfr.202200825
  18. Darshita Panchal et al. (2023). Development and evaluation of novel krill oil-based clomiphene microemulsion as a therapeutic strategy for PCOS treatment. Drug Delivery and Translational Research, 13, 2254 - 2271. https://doi.org/10.1007/s13346-023-01304-z
  19. Emily N. C. Manoogian et al. (2021). Time-restricted eating for the prevention and management of metabolic diseases.. Endocrine reviews. https://doi.org/10.1210/endrev/bnab027
  20. Burhan Kantawala et al. (2023). Physical activity intervention for the prevention of neurological diseases. Health Science Reports, 6. https://doi.org/10.1002/hsr2.1524
  21. Shaza Asif et al. (2020). Understanding Dietary Intervention-Mediated Epigenetic Modifications in Metabolic Diseases. Frontiers in Genetics, 11. https://doi.org/10.3389/fgene.2020.590369
  22. Chao-Yue Sun et al. (2022). Targeting Gut Microbiota With Natural Polysaccharides: Effective Interventions Against High-Fat Diet-Induced Metabolic Diseases. Frontiers in Microbiology, 13. https://doi.org/10.3389/fmicb.2022.859206
  23. J. Kuzma et al. (2017). Prevention of metabolic diseases: fruits (including fruit sugars) vs. vegetables. Current Opinion in Clinical Nutrition and Metabolic Care, 20, 286–293. https://doi.org/10.1097/MCO.0000000000000378
  24. A. Toney et al. (2021). Immunomodulatory Role of Urolithin A on Metabolic Diseases. Biomedicines, 9. https://doi.org/10.3390/biomedicines9020192
  25. X. Heng et al. (2015). [The New Idea about Early Intervention for Type 2 Diabetes Based on Gan Disease Transferring to Pi in Metabolic Diseases].. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 35 6, 746-51 .
  26. Lu Lu et al. (2022). New insights into natural products that target the gut microbiota: Effects on the prevention and treatment of colorectal cancer. Frontiers in Pharmacology, 13. https://doi.org/10.3389/fphar.2022.964793
  27. Helda Tutunchi et al. (2020). The Effects of Diets Enriched in Monounsaturated Oleic Acid on the Management and Prevention of Obesity: a Systematic Review of Human Intervention Studies.. Advances in nutrition. https://doi.org/10.1093/advances/nmaa013
  28. Z. Luo, H. Yan, and X. Pan, ‘Optimizing Transformer Models for Resource-Constrained Environments: A Study on Model Compression Techniques’, Journal of Computational Methods in Engineering Applications, pp. 1–12, Nov. 2023, doi: 10.62836/jcmea.v3i1.030107.
  29. H. Yan and D. Shao, ‘Enhancing Transformer Training Efficiency with Dynamic Dropout’, Nov. 05, 2024, arXiv: arXiv:2411.03236. doi: 10.48550/arXiv.2411.03236.
  30. Y. Liu and J. Wang, ‘AI-Driven Health Advice: Evaluating the Potential of Large Language Models as Health Assistants’, Journal of Computational Methods in Engineering Applications, pp. 1–7, Nov. 2023, doi: 10.62836/jcmea.v3i1.030106.
  31. Y. Gan and D. Zhu, ‘The Research on Intelligent News Advertisement Recommendation Algorithm Based on Prompt Learning in End-to-End Large Language Model Architecture’, Innovations in Applied Engineering and Technology, pp. 1–19, 2024.
  32. D. Zhu, Y. Gan, and X. Chen, ‘Domain Adaptation-Based Machine Learning Framework for Customer Churn Prediction Across Varing Distributions’, Journal of Computational Methods in Engineering Applications, pp. 1–14, 2021.
  33. H. Zhang, D. Zhu, Y. Gan, and S. Xiong, ‘End-to-End Learning-Based Study on the Mamba-ECANet Model for Data Security Intrusion Detection’, Journal of Information, Technology and Policy, pp. 1–17, 2024.
  34. D. Zhu, X. Chen, and Y. Gan, ‘A Multi-Model Output Fusion Strategy Based on Various Machine Learning Techniques for Product Price Prediction’, Journal of Electronic & Information Systems, vol. 4, no. 1.
  35. P. Ren and Z. Zhao, ‘Parental Recognition of Double Reduction Policy, Family Economic Status And Educational Anxiety: Exploring the Mediating Influence of Educational Technology Substitutive Resource’, Economics & Management Information, pp. 1–12, 2024.
  36. Z. Zhao, P. Ren, and Q. Yang, ‘Student self-management, academic achievement: Exploring the mediating role of self-efficacy and the moderating influence of gender insights from a survey conducted in 3 universities in America’, Apr. 17, 2024, arXiv: arXiv:2404.11029. doi: 10.48550/arXiv.2404.11029.
  37. P. Ren, Z. Zhao, and Q. Yang, ‘Exploring the Path of Transformation and Development for Study Abroad Consultancy Firms in China’, Apr. 17, 2024, arXiv: arXiv:2404.11034. doi: 10.48550/arXiv.2404.11034.
  38. Z. Zhao, P. Ren, and M. Tang, ‘How Social Media as a Digital Marketing Strategy Influences Chinese Students’ Decision to Study Abroad in the United States: A Model Analysis Approach’, Journal of Linguistics and Education Research, vol. 6, no. 1, pp. 12–23, 2024.
  39. Z. Zhao, P. Ren, and M. Tang, ‘Analyzing the Impact of Anti-Globalization on the Evolution of Higher Education Internationalization in China’, Journal of Linguistics and Education Research, vol. 5, no. 2, pp. 15–31, 2022.
  40. M. Tang, P. Ren, and Z. Zhao, ‘Bridging the gap: The role of educational technology in promoting educational equity’, The Educational Review, USA, vol. 8, no. 8, pp. 1077–1086, 2024.